The Trial is Over and the Verdict is Out; Results of Joe's 30-Day Microdosing Journey
By Courtney Holmes, RN, IFNCP — Founder, Eleeo Health & Wellness
When we began sharing Joe’s journey with psilocybin microdosing, we did it to bring light to a conversation that most of the world still refuses to have. But what we didn’t expect was the outpouring of questions, support, and shared stories from others desperate for hope, healing, and real answers.
Now, after tracking 30 days of microdosing in detail — symptoms, mood, movement, cognition, and daily functioning — we’re ready to share the data behind what we’ve been saying all along:
Psilocybin isn’t just promising. It’s powerful.
The Protocol
Joe followed a microdosing protocol using psilocybin, supported by the same nutritional and supplemental regimen he’s maintained since his diagnosis. Doses were spaced across four weeks and adjusted in real time based on his symptom feedback, mood, sleep, and activity level.
We began with 100mg, gradually increasing to 125mg, 150mg, 200mg, and eventually a one-time dose of 225mg. Because there is no established psilocybin protocol for Parkinson’s, we tailored this approach based on Joe’s day-to-day needs. Each dose was stacked with 2,000mg of Lion’s Mane and his B-complex supplement containing niacin.
We chose to dose daily — seven days a week. With Parkinson’s, we wanted to keep the neurogenesis and plasticity active to help the brain form new neurons and pathways. One reason people often take breaks is to reset tolerance, but Joe never developed one. In fact, by the end of the month, we had scaled the dose back down to 100–125mg based on how he felt.
He did take two rest days during the 30-day period — and interestingly, felt incredible on those days.
After Ibogaine therapy is complete, we will be reevaluating his protocol moving forward. It likely won’t follow a daily schedule — but more on that soon.
What We Tracked
Each day, we recorded over 30 individual symptom scores across three key categories using a 0–10 scale, with 10 indicating the most severe symptom presentation and 0 indicating no symptoms at all.
Motor Symptoms: tremors, dystonia, foot drag, gait, muscle stiffness, bradykinesia (slowness), fine motor skills (handwriting, utensil use), ability to rise from seated positions, walking distance, restless legs..
Non-Motor Symptoms: anxiety, depression, apathy, cognitive fog/memory, sleep quality, emotional regulation, fatigue, headache, energy, dizziness on standing, loss of smell.
Pain & Functional Ability: shoulder pain, hip pain, back pain, leg pain, right hand function, hand dexterity, exercise capacity, ability to complete daily tasks (e.g., dressing, stairs).
The Results
Motor Symptoms
Average severity dropped from 8.1 to 1.6 — an 80.2% improvement.
Notable gains included:
Reduced tremor intensity (arm and leg)
Dramatically improved gait and fluidity of movement
Improved ability to rise from seated positions
Increased walking endurance and coordination
Return of fine motor control in right hand
Marked reduction in dystonia — a previously painful and unpredictable symptom — resulting in smoother, more fluid movement, improved stability, and even the ability to run again for the first time in years
Non-Motor Symptoms
Severity decreased from 9.3 to 1.7 — an 81.7% improvement
Anxiety, depression, and apathy nearly resolved
Noticeable cognitive gains in memory, focus, and executive functioning
Mood stabilized, sleep consistency and emotional resilience returned
Facial expression and motivation improved significantly
Pain & Functional Ability
Severity improved from 7.9 to 1.5 — a 78.3% reduction in pain and limitations.
Shoulder and hip pain significantly reduced
Right hand strength and dexterity restored
Less joint stiffness and greater physical confidence
Dramatic improvement in ability to complete everyday activities
Improved strength and stamina during activities like walking and running
Other Symptoms
Scores decreased from 10.0 to 3.2 — a 68.0% improvement
Dizziness resolved, handwriting legibility improved
Better balance, posture, and sleep
Emotional Wellness
Unlike other symptoms, mood was tracked on a scale where 10 represented the best possible mood and 0 the lowest.
Joe’s mood score rose from a baseline of 5 to a steady 8–9. But more importantly: his joy returned. His presence returned.
Our daughters saw their dad come back to life — not just functioning, but thriving.
What This Means
We aren’t claiming psilocybin is a cure for Parkinson’s. But this data, combined with Joe’s lived experience, aligns with what early research has been suggesting:
Psilocybin promotes neuroplasticity, which may enhance motor learning, memory formation, and executive function through increased dendritic growth and synaptic remodeling.
It acts primarily on the serotonin 2A (5-HT2A) receptor, which plays a key role in regulating mood, inflammation, sensory processing, and neural pathways involved in movement.
Psilocybin helps "reset" the brain’s Default Mode Network (DMN) — a network associated with self-referential thinking and rumination — potentially relieving cognitive fog, emotional rigidity, and depression, which are common in Parkinson’s.
Psychospiritual growth supports resilience, motivation, and emotional clarity — elements traditional medicine often ignores.
These aren’t just hopeful ideas. They’re measurable outcomes. And we have the numbers to prove it.
Why We’re Speaking Up
Joe is not alone. There are thousands living with Young-Onset Parkinson’s and traditional treatment plans that barely scratch the surface of what they need — mentally, emotionally, or physically. They are searching for better answers — and finding nothing new in a broken system.
The system says:
“Wait until your symptoms get worse.”
“Here’s a pill to mask it — and another for the side effects.”
“Come back in six months.”
We say: Start sooner. Go deeper. Ask better questions.
There is a better way —- and the world needs to hear about it.
A Note of Caution
We share this as advocates, not prescribers. Psilocybin remains federally restricted in the U.S., and we cannot provide, recommend, or facilitate access to it. Always speak with a licensed medical professional and understand your state’s laws.
The Parkinson’s Project Foundation has teamed up with Eleeo Health and Wellness to offer discounted consultations starting in August for Parkinson’s patients seeking guidance on nutrition, lifestyle interventions, and alternative therapies that may help stabilize symptoms and support overall healing. Stay tuned for more information and to book your consultation.
Daily Symptom Tracking Visuals
Below are real data visualizations from Joe’s 30-day psilocybin microdosing trial, showing daily symptom tracking across motor, non-motor, and functional categories. This transparent, patient-led data gives a clearer picture of what healing can actually look like.
What’s Next
We’re in this for the long haul. The Parkinson’s Project Foundation is:
Building partnerships
Developing a grant program for those seeking legal psychedelic-assisted therapies
Continuing to publish transparent, patient-led data that demands attention
Fighting to remove the stigma, elevate the science, and change the laws
If this resonated with you, share it. Talk about it. Ask questions.
Let’s keep the conversation going — because the future of Parkinson’s care shouldn’t be locked away by outdated laws and outdated thinking.
We’re just getting started. And we’ll keep going until every patient has access to real healing, real hope, and real choice.
